Orthotopic Models

Renal Sub-Capsule Orthotopic Model

The renal orthotopic model has been developed for the efficacy evaluation of novel anti-cancer compounds using a model that mimics the disease process in humans. Cell lines utilized in this model, include 786-O and Caki-1.

Orthotopic Models


Intracranial Orthotopic Model

Intracranial injection of tumor cells mimics clinical responses to tumor growth. Test agent effects are evaluated based on clinical observations and sample analyses. We have used D54-MG-luc and U87MG human gliomas models successfully in mice.

Intracranial Orthotopic Model


Hepatic Orthotopic Model

Orthotopic seeding of human tumor cell lines allows assessment of tumor development in the host organ and provides efficacy evaluation in a preclinical model mimicking disease process in humans. This allows for a more representative picture of tumor growth and response to therapy scenario to be realized.

Hepatic Orthotopic Model

Orthotopic Prostate Tumor Model

Piedmont Research Center offers an orthotopic prostate model using a luciferase-expressing PC-3M-luc line. Both standard chemotherapy and radiation treatments have been validated in this model.

Orthotopic Breast Tumor Model

Either BT474 or MX-1 cancer lines can be injected directly into the mammary fat pad of the mouse in this orthotopic model. With our luciferase-tagged MDA-MB231 cell line, spontaneous metastases can be quantified in lymph nodes within five weeks of implantation.

Systemic Leukemia/Lymphoma Model

In this model, Raji-B tumor cells are injected by IV tail vein. Clinical signs associated with progression of tumor include impairment of hind limb function, ocular proptosis and weight loss.